Experience in conducting studies, continuous feedback from international authorities and the continuous implementation of new studies to meet new regulatory requirements are the forces that have allowed us to become the ideal partner for the registration of agrochemical products and a key player in the research and development of new products. What distinguishes our offer is the ability to integrate these levels of experience and innovation with the analytical requirements of the reference regulations, such as Regulation (EC) no. 1107/2009 regarding agropharmaceuticals and Regulation (EU) 2019/1009 regarding fertilisers and biostimulants. We can provide advanced analytical solutions that fully meet regulatory requirements, helping you achieve success in registering your products in compliance with current regulations.
Our experience
+ 30 years of experience in our Test Center
Study Directors with specific experience in various fields and seniority from 5 to +30 years.
The innovation we deploy
Strategic support to respond to the new requirements of international regulatory authorities.
Development of new methods and adaptation to guidelines.
Use of latest generation equipment to guarantee reliable results.
5-batch analysis
Tests and analyses are performed in these fields:
Preliminary screening of active substance, relevant and significant impurities, metals, ions and solvents
5-batch analysis (analysis of active substance, relevant and significant impurities, water content)
Separation of impurities by preparative HPLC
Spectra (UV/Vis, IR, MS, NMR)
Certificates of analysis
Physical-chemical properties and storage stability
Our laboratories are able to carry out the analyses required for the chemical-physical characterisation of technical products and formulations established by the Regulatory Authorities completely independently. These can be performed on both conventional products and natural extracts used as low-risk pesticides. We have also developed significant experience with hybrid formulations.
Physical-chemical properties for technical products
UV-VIS, FT-IR, MS
Water and Solvent solubilites
Partition coefficient (Octanol/water)
Vapour pressure
Melting and boiling points
Freezing point
Dissociation constant
Abiotic degradation hydrolysis
Hazardous physical properties
Flammability and auto-flammability
Explosive properties test (shock test, friction, Koenen thermal sensitivity)
Emulsifiability, re-emulsifiability and emulsion stability
Particle size distribution
Dustiness
Attrition charateristics
Persistent foam
Pourability
Surface tension
Viscosity
Miscibility with hydrocarbon oil
Flowability of granular preparations
Washing efficacy
Seed-to seed uniformity of distribution
Adhesion to treated seeds
Hazard properties
Explosive properties with DSC screening test
Explosive properties for liquids and solids
Flash point and flammability
Auto-ignition temperature (liquids) and Self-Ignition temperature (solid)
Oxidizing properties for liquids and solids
Stability studies
Accelerated storage stability (different times and temperatures)
Low temperature stability
Shelf life stability (different times and temperatures)
Method development and validation
The large number of state-of-the-art instruments and the specific experience of the Study Directors guarantee the reliability and quality of the studies performed in the unit.
Quadrupole-Orbitrap Hybrid Mass Spectrometers offer the advantages of a combination of scanning speed, high resolution, mass accuracy, wide linearity range, spectral quality and sensitivity to allow trace and untarget analyses, making retrospective screening possible.
The presence of two independent GLP-certified assay centres also allows ILVs to be performed in-house.
Some of the services offered:
Validation and analysis of technical products and formulations (SANCO/3030/99 rev.5)
Validation and residue analysis according to SANTE/2020/12830 rev.1
ILV (Independent Laboratory Validation)
Residue analysis
The large number of state-of-the-art instruments and the specific experience of the Study Directors guarantee the reliability and quality of the studies performed in the unit.
Determination of traces of active substances and its metabolites in different plant matrices (management of field and laboratory part)
Residue stability studies in different matrices and different cultures (storage stability)
Trace determination in environmental impact studies from laboratory to field (soil dissipation), among the matrices analysed were:
Water
Soil
Sediment
Bioaccumulation studies in different environmental compartments
Methods for the quantification of active ingredients and metabolites in air
Development of analytical methods for the quantification of trace substances in animal matrices (muscle, fat, liver, kidney and body fluid). We are also able to follow the drug kinetics of these substances through analytical determinations.
Environmental- fate (e-fate)
Environmental impact studies are important with a view to registration for both active substances and formulated products; below are some of the studies we are able to carry out in accordance with the guidelines:
Aerobic and anaerobic transformation in soil (OECD 307)
Aerobic and anaerobic transformation in aquatic sediment (OECD 308)
Absorption and desorption using batch equilibrium method (OECD 106)
Hydrolysis as a function of pH (OECD 111)
Phototransformation of chemicals in water and direct photohydrolysis (OECD 316)
Estimation of sorption coefficient in soil and sludge using HPLC
Biodegradability - manometric respirometry (OECD 301 F - D)
Respiratory inhibition test with activated sludge (OECD 209)
Acquatic, terrestrial ecotoxicology and pollinators
Experienced study directors, state-of-the-art facilities and state-of-the-art equipment in the ecotoxicology unit have enabled LabAnalysis Life Science to become an international centre of excellence for this type of study.
The experience gained over the years in the preparation of UVCB substance assays according to OECD guideline 23, and the experience in environmental and pharmaceutical matrices, have enabled LabAnalysis Life Science to expand its ecotoxicological assay offering to a wide range of matrices to be tested, from agrochemicals to waste, end-of-waste products and drugs.
The reconstituted water production facility and the recent implementation of the new fish assay system also allow long-term testing from the embryonic stage of fish through to development (FET, FELS). Furthermore, it is possible to test for the potential of chemicals as endocrine disruptors.
Aquatic ecotoxicity
Short-term studies:
Acute test under static or semi-static regime with Daphnia magna according to EU C.2, OECD 202, USA OPPTS850.1010
Algal growth test: Scenedesmus subspicatus, Pseudokirchneriella subcapitata, Anaboena flos aquae according to EU C.3, OECD 201, USA OPPTS 850.5400
Acute fish mortality test: Danio rerio, Oncorhynchus mykiss according to EU C.1, OECD 203; USA OPPTS 850.1075
Acute Fish Embryo Test -(FET) Test according to OECD 236.
Lemna sp. growth inhibition test according to OECD 221, USA OPPTS 850.4400
Test for aquatic plant growth toxicity: Myriophyllum aquaticum according to OECD 238 (without sediment), OECD 239 (with sediment)
Acute immobilisation test for Chironomus sp. according to OECD 235
Long-term studies:
FELS test under static, semi-static or continuous flow according to OECD 210
Juvenile fish growth test according to OECD 215
Long-term toxicity test on crustacean reproduction: Daphnia Magna according to EU.20, OECD 211 and US OPPTS 850.1300
Terrestrial ecotoxicity
Short-term studies:
Acute worm toxicity test: Eisenia fetida according to EU C.8, OECD 207
Toxicity test on soil microorganisms - inhibition of nitrification capacity according to OECD 216, EU C.21
Toxicity test on soil microorganisms - inhibition on carbonation capacity according to OECD 217, EU C.22 Long-term test
Chronic toxicity test on worms: Eisenia fetida - OECD 222
Sub-lethal toxicity test on worms: Eisenia fetida - US OPPTS 850.6200
Terrestrial plants - emergence and growth test according to OECD 208
Terrestrial plants - vigour test according to OECD 227
Non-target soil organisms: Folsomia candida and Hypoaspis aculeifer according to OECD 232, OECD 226
Non-target arthropods (NTA)
Test Aphidius rhopalosiphi (parasitic wasp) according to IOBC / WPRS 2000
Typhlodromus pyri test according to IOBC / WPRS 2000
Chrysoperla carnea
Coccinella septempunctata
Orius laevigatus
Aleochara bilineata
Poecilus cupreus
Pardosa spec.
Bee tests
Oral and contact toxicity test for pollinators on adults of Apis mellifera (honey bee) according to OECD 213/214
Acute contact and oral toxicity test on adults of Bombus terrestris L. (bumblebee) according to OECD 246/247
Larval toxicity test - single and multiple exposure on Apis Mellifera (honey bee) according to OECD 237 (single exposure) and OECD 239 (multiple exposure)
Chronic oral toxicity test (feeding for 10 days) on adults of Apis Mellifera (honey bee) according to OECD 245
Bee brood test under semi-field conditions according to OECD 75
EPPO 170: field study of honey bees
Oomen method (Oomen et al., 1992): brood feeding study of honey bees
Field studies on honey bees according to EFSA guidance (EFSA, 2013)
SANTE/11956/2016 rev. 9 Residue tests for the establishment of MRLs in honey
In-vitro toxicology and mutagenicity test
Qualified Study Directors can support clients in their in vitro testing strategy to achieve human risk classification quickly, cost-effectively and without the use of animals, as required by current European regulations.
Tests performed
In vitro toxicology and mutagenesis tests:
In vitro toxicology and mutagenesis studies
Skin irritation and corrosion in vitro (OECD 439, OECD 431)
Eye irritation and corrosion in vitro(OECD 492, OECD 437)
Ames test (OECD 471)
Microbiology and molecular biology
I am interested in the service Agrochemicals and biopesticides
